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2b) and noted that evolved variants also cleaved ORC1 (residues 691707) in the luminescence assay (Extended Data Fig
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Individuals who are pregnant, breastfeeding, or have G6PD deficiency should avoid this treatment
Because MOTS-c enhances insulin-independent glucose uptake, patients with type 1 diabetes or those using exogenous insulin should be monitored carefully to prevent hypoglycemia, though this theoretical risk has not materialized in clinical reports to date
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